Reaction #1889

Reaction equation

2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol

trifluoroacetic acid

sodium hydrogen carbonate

→

crystal

Yield 95.7%

5-chloro-α-(2-chlorophenyl)-2-(trifluoroacetylamino)benzyl alcohol

Yield 95.7%

Solvents

dichloromethane

dichloromethane

Conditions

Workup

1. 1
   OtherAfter reaction
2. 2
   Otherthe organic layer was dried
3. 3
   Otherafter which the solvent was removed
4. 4
   Otherthe residue was recrystallized from hexane

Procedure

To a solution of 1.0 g of 2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol in 12 ml of dichloromethane, a solution of 0.8 g of anhydrous trifluoroacetic acid in 2 ml of dichloromethane was added. After reaction, an aqueous solution of sodium hydrogen carbonate was added, and the organic layer was dried, after which the solvent was removed and the residue was recrystallized from hexane to yield 1.3 g of a crystal.

Source