Reaction #1876820

Reaction equation

1,3,5-trihydroxyadamantane

trimethylamine

trimethylsilyl chloride

→

1,3-dihydroxy-5-trimethylsiloxyadamantane

Solvents

methylene chloride

Conditions

Workup

1. 1
   OtherReaction
2. 2
   Otherwas carried out at room temperature
3. 3
   OtherThe reaction product was partitioned by high performance liquid chromatography

Procedure

This 1,3,5-trihydroxyadamantane was dissolved in methylene chloride. To this solution were added a small amount of trimethylamine, and then an equimolar amount of trimethylsilyl chloride. Reaction was carried out at room temperature. The reaction product was partitioned by high performance liquid chromatography to obtain 1,3-dihydroxy-5-trimethylsiloxyadamantane.

Source