Reaction #1875676

Reaction equation

KOH

1-(4-morpholin-4-yl-phenyl)-ethanone

Compound 354

2-[2-(5-Bromo-2-hydroxy-phenyl)-quinolin-6-yl]-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid

→

title compound

Yield 30.0%

1-cyclohexyl-2-[2-(4-morpholin-4-yl-phenyl)-quinolin-6-yl]-1H-benzoimidazole-5-carboxylic acid

Yield 30.0%

Solvents

ethanol

ethanol

Conditions

Procedure

Following the procedure and workup for Compound 354, Compound 354e (100 mg, 0.256 mmol) was reacted with 1-(4-morpholin-4-yl-phenyl)-ethanone (0.256 mmol) in ethanol (2 mL) using 10% w/v KOH in ethanol (506 μL, 0.64 mmol) to produce the title compound (37 mg, 30% yield). MS: 533.28 (M+H+); HPLC Procedure A, retention time=10.39 min.

Source