Reaction #1857547

Reaction equation

dichloro methane

sodium hydride

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)but-3-en-2-ol

methyl iodide

→

desired compound

1-[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-methoxy-but-3-enyl]-1,2,4-triazole

Solvents

Brine

THF

Conditions

Workup

1. 1
   TemperatureThe mixture was then heated for 10 h
2. 2
   Temperatureto reflux
3. 3
   Otherthe organic phase was dried
4. 4
   Otherevaporated
5. 5
   Otherto obtain the crude product
6. 6
   OtherThis was purified by column chromatography

Procedure

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)but-3-en-2-ol (0.4 g) was dissolved in THF (10 mL) and sodium hydride (0.03 g) was added. The mixture was stirred for 30 min at room temperature and methyl iodide (0.08 mL) was added. The mixture was then heated for 10 h to reflux. Brine and dichloro methane were added, the organic phase was dried and evaporated to obtain the crude product. This was purified by column chromatography to obtain 0.04 g of the desired compound.

Source