Reaction #1839

ord-61857a4aa4ad49af8aac9e9223a18f71

Reaction equation

O=[N+]([O-])c1ccc(O)cc1CO
5-hydroxy-2-nitrobenzyl alcohol
CC(C)I
isopropyl iodide
→
CC(C)Oc1ccc([N+](=O)[O-])c(CO)c1
2-Nitro-5-(2-propyloxy)benzyl alcohol

Reactants

O=[N+]([O-])c1ccc(O)cc1CO
5-hydroxy-2-nitrobenzyl alcohol
CC(C)I
isopropyl iodide

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherafter purification over silica gel with n-heptane/ethyl acetate (3:2), 10.3 g of oily crude product

Procedure

10 g (60 mmol) of 5-hydroxy-2-nitrobenzyl alcohol were reacted with 7.0 ml (70 mmol) of isopropyl iodide analogously to Example 4a); after purification over silica gel with n-heptane/ethyl acetate (3:2), 10.3 g of oily crude product.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05726305uspto-grants-1998_03