Reaction #1810836

ord-1819011266ed44bbb0e0ad592c19e685

Reaction equation

CCOc1cc(C=O)ccc1OC
3-ethoxy-4-methoxybenzaldehyde
CC(=O)O
acetic acid
Cc1nnc(SCc2ccccc2F)n(N)c1=O
4-amino-3-(2-fluorobenzylsulfanyl)-6-methyl-4H-1,2,4-triazin-5-one
CCOc1cc(C=Nn2c(SCc3ccccc3F)nnc(C)c2=O)ccc1OC
4-[(3-ethoxy-4-methoxybenzylidene)amino]-3-(2-fluorobenzylsulfanyl)-6-methyl-4H-1,2,4-triazin-5-one

Solvents

Conditions

Temperature
65°CELSIUS
Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    FiltrationThe resultant precipitate was filtered off with suction

Procedure

0.054 g of 3-ethoxy-4-methoxybenzaldehyde and 0.017 ml of acetic acid were added to a solution of 0.080 g of 4-amino-3-(2-fluorobenzylsulfanyl)-6-methyl-4H-1,2,4-triazin-5-one in 4 ml of ethanol, and the mixture was stirred at 65° C. The resultant precipitate was filtered off with suction, giving 4-[(3-ethoxy-4-methoxybenzylidene)amino]-3-(2-fluorobenzylsulfanyl)-6-methyl-4H-1,2,4-triazin-5-one.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07485639B2uspto-grants-2009_02