Reaction #1810834

ord-c02e75907e344895b83643a485925b07

Reaction equation

CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)O)c1
2-cyclopropylmethoxy-5-methanesulfonyl-benzoic acid
Cl.Clc1ccc(C2=CCNCC2)cc1
4-(4-chloro-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride
→
CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)N2CC=C(c3ccc(Cl)cc3)CC2)c1
title compound
CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)N2CC=C(c3ccc(Cl)cc3)CC2)c1
[4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-(2-cyclopropylmethoxy-5-methanesulfonyl-phenyl)-methanone

Reactants

CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)O)c1
2-cyclopropylmethoxy-5-methanesulfonyl-benzoic acid
Cl.Clc1ccc(C2=CCNCC2)cc1
4-(4-chloro-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherdescribed for the synthesis of example 4, step f

Procedure

According to the procedure described for the synthesis of example 4, step f, the title compound has been synthesized from 2-cyclopropylmethoxy-5-methanesulfonyl-benzoic acid (CAS: 845616-03-7) and 4-(4-chloro-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride (commercial). MS (m/e): 446.0 (MH+, 100%).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07485637B2uspto-grants-2009_02