Reaction #1810828

ord-f1fdb6e54e1b44aabe78519daca2f998

Reaction equation

O=C(O)c1cc([N+](=O)[O-])ccc1N1CCOCC1
2-Morpholin-4-yl-5-nitro-benzoic acid
CS(=O)(=O)c1ccc(C2=CCNCC2)cc1
4-(4-Methanesulfonyl-phenyl)-1,2,3,6-tetrahydro-pyridine
→
CS(=O)(=O)c1ccc(C2=CCN(C(=O)c3cc([N+](=O)[O-])ccc3N3CCOCC3)CC2)cc1
title compound
CS(=O)(=O)c1ccc(C2=CCN(C(=O)c3cc([N+](=O)[O-])ccc3N3CCOCC3)CC2)cc1
[4-(4-Methanesulfonyl-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-(2-morpholin-4-yl-5-nitro-phenyl)-methanone

Reactants

O=C(O)c1cc([N+](=O)[O-])ccc1N1CCOCC1
2-Morpholin-4-yl-5-nitro-benzoic acid
CS(=O)(=O)c1ccc(C2=CCNCC2)cc1
4-(4-Methanesulfonyl-phenyl)-1,2,3,6-tetrahydro-pyridine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherdescribed for the synthesis of example 4, step f

Procedure

According to the procedure described for the synthesis of example 4, step f, the title compound has been synthesized from 2-Morpholin-4-yl-5-nitro-benzoic acid and 4-(4-Methanesulfonyl-phenyl)-1,2,3,6-tetrahydro-pyridine. MS (m/e): 470.1 (M−H, 100%)

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07485637B2uspto-grants-2009_02