Reaction #1810827

ord-ccabd61116b549dfa48cefeceb145a91

Reaction equation

CS(=O)(=O)c1ccc(N2CCOCC2)c(C(=O)O)c1
5-Methanesulfonyl-2-morpholin-4-yl-benzoic acid
FC(F)(F)c1ccc(C2=CCNCC2)cc1
4-(4-Trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine
→
CS(=O)(=O)c1ccc(N2CCOCC2)c(C(=O)N2CC=C(c3ccc(C(F)(F)F)cc3)CC2)c1
title compound
CS(=O)(=O)c1ccc(N2CCOCC2)c(C(=O)N2CC=C(c3ccc(C(F)(F)F)cc3)CC2)c1
(5-Methanesulfonyl-2-morpholin-4-yl-phenyl)-[4-(4-trifluoromethyl-phenyl)-3,6dihydro-2H-pyridin-1-yl]-methanone

Reactants

CS(=O)(=O)c1ccc(N2CCOCC2)c(C(=O)O)c1
5-Methanesulfonyl-2-morpholin-4-yl-benzoic acid
FC(F)(F)c1ccc(C2=CCNCC2)cc1
4-(4-Trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherdescribed for the synthesis of example 4, step f

Procedure

According to the procedure described for the synthesis of example 4, step f, the title compound has been synthesized from 5-Methanesulfonyl-2-morpholin-4-yl-benzoic acid and 4-(4-Trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine. MS (m/e): 495.4 (MH+, 100%)

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07485637B2uspto-grants-2009_02