Reaction #1810815

Reaction equation

2-fluoro-5-nitrobenzoic acid

morpholine

→

title compound

Yield 93.0%

2-Morpholin-4-yl-5-nitro-benzoic acid

Yield 93.0%

Solvents

dioxane

Conditions

Workup

1. 1
   OtherThe solvent was removed in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water
3. 3
   FiltrationThe solid was filtered
4. 4
   Washwashed with water
5. 5
   Otherdried

Procedure

To a solution of 2-fluoro-5-nitrobenzoic acid (4.86 g, 26.2 mmol) in dioxane (50 ml) was added morpholine (11.5 ml). The mixture was stirred at room temperature for 2 hours. The solvent was removed in vacuo. The residue was dissolved in water and the mixture was acidified with HCl 2N. The solid was filtered, washed with water and dried to provide the title compound (6.2 g, 93%) as a yellow solid, MS (m/e): 251.2 (M−H, 100%).

Source