Reaction #1810808

Reaction equation

methyliodide

[4-(1,3-dimethyl-thioureido)-cyclohexyl]carbamic acid benzylester

→

hydroiodide

[4-(1,2,3-Trimethyl-isothioureido)-cyclohexyl]-carbamic acid benzylester

Solvents

AcCN

Conditions

Workup

1. 1
   OtherThe mixture obtained
2. 2
   Temperatureis refluxed for 2.5 hours
3. 3
   Othersolvent is evaporated

Procedure

0.18 ml of methyliodide are added to a solution of 0.64 g [4-(1,3-dimethyl-thioureido)-cyclohexyl]carbamic acid benzylester in 30 ml of AcCN. The mixture obtained is refluxed for 2.5 hours and solvent is evaporated. [4-(1,2,3-Trimethyl-isothioureido)-cyclohexyl]-carbamic acid benzylester in the form of a hydroiodide is obtained.

Source