Reaction #1810807

Reaction equation

H2O

1-(4-dimethylaminocyclohexyl)-3-methyl-thiourea

methyliodide

HCl

→

1-(trans-4-Dimethylamino-cyclohexyl)-2,3-dimethyl-isothiourea

hydrochloride

Solvents

chloride

MeOH

Conditions

Workup

1. 1
   OtherFrom the mixture obtained solvent
2. 2
   Otheris evaporated
3. 3
   Otherthe evaporation residue obtained
4. 4
   Otherobtained
5. 5
   Otherthe mixture obtained
6. 6
   workup.STIRRINGis stirred at RT
7. 7
   OtherA precipitate obtained
8. 8
   Filtrationis filtrated off
9. 9
   Otherthe filtrate obtained

Procedure

A mixture of 0.50 g of 1-(4-dimethylaminocyclohexyl)-3-methyl-thiourea in 10 ml of MeOH, 1.16 ml of 2M HCl (in MeOH) and 0.36 g of methyliodide is stirred at RT. From the mixture obtained solvent is evaporated and the evaporation residue obtained is treated with H2O. 10 ml of a strong basic ion exchanger in chloride form (Amberlite IRA 400 (Cl)R) are added to the aqueous mixture obtained and the mixture obtained is stirred at RT. A precipitate obtained is filtrated off and the filtrate obtained is lyophilized. 1-(trans-4-Dimethylamino-cyclohexyl)-2,3-dimethyl-isothiourea in the form of a hydrochloride is obtained.

Source