Reaction #1810796

Reaction equation

ethyl 3-hydroxybutyrate

ethyl 4-cyano-3-hydroxybutyrate

→

ethyl (R)-4-cyano-3-hydroxybutyrate

Yield 99.0%

Conditions

Workup

1. 1
   OtherAfter reaction for 3 hours

Procedure

Instead of ethyl 3-hydroxybutyrate used in Example 1, ethyl 4-cyano-3-hydroxybutyrate (1%, w/v) was used as a reactant and novozyme 435 lipase was used as a biocatalyst. After reaction for 3 hours, ethyl (R)-4-cyano-3-hydroxybutyrate (99% e.e) was obtained at 57.3% conversion.

Source