Reaction #1797478

ord-49530173db4a46ca88018fc46e3407e0

Reaction equation

CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O
chlorpheniramine maleate
→
CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1
Chlorpheniramine

Reactants

CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O
chlorpheniramine maleate
—
ion-exchange

Reagents

None

Solvents

O
water

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Washthe product washed with USP water
  2. 2
    OtherThe wet cake was dried
  3. 3
    Filtrationsieved through a US Std #30 mesh screen

Procedure

Chlorpheniramine polistirex was prepared by mixing 3.12 kg of chlorpheniramine maleate with 26.00 kg of ion-exchange resin particles (AMBERLITE IRP69; US Std. Mesh #100-#400) suspended in USP water at about 30° C. The resulting suspension was centrifuged and the product washed with USP water. The wet cake was dried and sieved through a US Std #30 mesh screen. The chlorpheniramine content of the dried product was equivalent to approximately 11% by weight.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07790201B2uspto-grants-2010_09