Reaction #1797477

ord-3a00c46f6d414577a79f339f96b9c5d2

Reaction equation

COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314.O=C(O)C(O)C(O)C(=O)O
hydrocodone bitartrate
→
COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314
Hydrocodone

Reactants

COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314.O=C(O)C(O)C(O)C(=O)O
hydrocodone bitartrate
—
ion-exchange

Reagents

None

Solvents

O
water

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Washthe product washed with USP water
  2. 2
    OtherThe wet cake was dried
  3. 3
    Filtrationsieved through a US Std #30 mesh screen

Procedure

Hydrocodone polistirex was prepared by mixing 4.00 kg of hydrocodone bitartrate with 4.76 kg of ion-exchange resin particles (ABMERLITE IRP69; US Std. Mesh #100-#400) suspended in USP water at about 70° C. The resulting suspension was centrifuged and the product washed with USP water. The wet cake was dried and sieved through a US Std #30 mesh screen. The hydrocodone content of the dried product was equivalent to approximately 56% by weight of hydrocodone bitartrate.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07790201B2uspto-grants-2010_09