Reaction #1771991

Reaction equation

Boc-Pro(4,4-diMe)-OH

thionylchloride

methanol

→

4,4-Dimethylproline Methylester Hydrochloride Salt

Conditions

Workup

1. 1
   ConcentrationThe reaction mixture was concentrated to an amorphous solid (377 mg, 95%)

Procedure

To a solution of Boc-Pro(4,4-diMe)-OH (0.5 g, 2.06 mmol) in anhydrous methanol (8 ml) was added dropwise thionylchloride (448 g, 6.18 mmol) and the reaction was stirred for six hours at room temperature. The reaction mixture was concentrated to an amorphous solid (377 mg, 95%).

Source