Reaction #1771990

ord-56238b79bf8e4876a8c816dff94dc2f6

Reaction equation

CC1(C)CN(C(=O)OC(C)(C)C)[C@@](C(=O)O)(C(C)(C)C)C1
tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline
→
CC1(C)CN[C@H](C(=O)O)C1
4,4-Dimethylproline

Reactants

CC1(C)CN(C(=O)OC(C)(C)C)[C@@](C(=O)O)(C(C)(C)C)C1
tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline

Reagents

None

Solvents

ClCCl
dichloromethane

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    ConcentrationThe solution was concentrated
  2. 2
    Otherdried under high vacuum
  3. 3
    Othertaken to the next step without further purification

Procedure

A solution of tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline in dichloromethane (5 mL) and trifluoroacetic (5 mL) was stirred at room temperature for five hours. The solution was concentrated, dried under high vacuum and taken to the next step without further purification.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: USRE043298E1uspto-grants-2012_04