Reaction #1747892

ord-50e5bc200660409ab864b4c6ebcabca0

Reaction equation

O=C(OCc1ccccc1)[C@@H]1CCCN1CC1CO1
compound 120
O=C(OCc1ccccc1)[C@@H]1CCCN1CC1CO1
N-Glycidyl-L-Proline Benzyl Ester
O.[Li+].[OH-]
LiOH H2O
→
O=C(O)[C@@H]1CCCN1CC1CO1
N-Glycidyl-L-proline

Reactants

—
benzyl ester
O=C(OCc1ccccc1)[C@@H]1CCCN1CC1CO1
compound 120
O=C(OCc1ccccc1)[C@@H]1CCCN1CC1CO1
N-Glycidyl-L-Proline Benzyl Ester
O.[Li+].[OH-]
LiOH H2O

Reagents

None

Solvents

CO
methanol

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

N-Glycidyl-L-proline is prepared from compound 120 by hydrolyzing the benzyl ester with LiOH/H2O in methanol.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08030279B2uspto-grants-2011_10