Reaction #1726725

Reaction equation

solution

1-(3-fluorophenyl)-3-(2-methyl-4-nitrophenyl)urea

hydrogen

→

1-(4-amino-2-methylphenyl)-3-(3-fluorophenyl)urea

Solvents

N,N-dimethylformamide

Conditions

Workup

1. 1
   FiltrationThe mixture was filtered
2. 2
   Extractionthe filtrate was extracted with ethyl acetate
3. 3
   ExtractionThe organic extract
4. 4
   Washwas washed with brine
5. 5
   Dryingdried with MgSO4
6. 6
   Concentrationconcentrated
7. 7
   Otherto provide EXAMPLE 100B

Procedure

A solution of EXAMPLE 100A (1.28 g, 4.43 mmol) in 12 mL of N,N-dimethylformamide was degassed and hydrogenated under an atmosphere of hydrogen (balloon) in the presence of catalytic amount of 10% Pd on carbon for 24 hours. The mixture was filtered and the filtrate was extracted with ethyl acetate. The organic extract was washed with brine, dried with MgSO4 and concentrated to provide EXAMPLE 100B. MS (ESI(+)) m/e 260 (M+H)+.

Source