Reaction #1726722

Reaction equation

benzyl 2-benzyloxy-5-(morpholin-4-yl)benzoate

2-benzyloxy-5-(morpholin-4-yl)benzamide

→

2-hydroxy-5-(morpholin-4-yl)benzamide

Yield 83.0%

Conditions

Procedure

In a manner identical to Example 140, 121 mg (0.30 mmol) of benzyl 2-benzyloxy-5-(morpholin-4-yl)benzoate is converted to 2-benzyloxy-5-(morpholin-4-yl)benzamide which on hydrogenolysis gives 56 mg (0.25 mmol, 83% yield) of 2-hydroxy-5-(morpholin-4-yl)benzamide.

Source