Reaction #1726705

Reaction equation

5-amino-1-(3′-nitrophenyl)-4-cyanopyrazole

phosphoric acid

ammonium hydroxide

→

5-amino-1-(3′-nitrophenyl)-pyrazole

Yield 80.0%

Conditions

Workup

1. 1
   ExtractionThe organics were extracted three times with diethyl ether (total 40 ml)
2. 2
   Washwashed with brine
3. 3
   Dryingdried over magnesium sulfate
4. 4
   OtherRemoval of solvent

Procedure

5-amino-1-(3′-nitrophenyl)-4-cyanopyrazole (559 mg, 2.44 mmol) and phosphoric acid (86%, 6 ml) were refluxed at 170° C. for 15 h. The reaction was cooled to room temperature and neutralized with ammonium hydroxide. The organics were extracted three times with diethyl ether (total 40 ml), washed with brine, and dried over magnesium sulfate. Removal of solvent gave 5-amino-1-(3′-nitrophenyl)-pyrazole as a yellow powder (398 mg, 80% yield).

Source