Reaction #1723970

ord-3f1a136b5efa48f0a75c17e10b2c8384

Reaction equation

Cl.Cl.N#Cc1ccc(N)c(CN2CC[C@H](N)C2=O)c1
4-amino-3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)benzonitrile dihydrochloride
O=S(=O)(Cl)c1cc2ccccc2s1
benzo[b]thiophene-2-sulfonyl chloride
CC#N
acetonitrile
→
N#Cc1cc(CN2CC[C@H](NS(=O)(=O)c3cc4ccccc4s3)C2=O)ccc1N
title compound
N#Cc1cc(CN2CC[C@H](NS(=O)(=O)c3cc4ccccc4s3)C2=O)ccc1N
Benzo[b]thiophene-2-sulfonic acid [1-(4-amino-3-cyanobenzyl)-2-oxo-pyrrolidin-3-(S)-yl]amide

Reactants

Cl.Cl.N#Cc1ccc(N)c(CN2CC[C@H](N)C2=O)c1
4-amino-3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)benzonitrile dihydrochloride
O=S(=O)(Cl)c1cc2ccccc2s1
benzo[b]thiophene-2-sulfonyl chloride
CC#N
acetonitrile

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound (0.131 g, 0.307 mmol) is prepared as in EXAMPLE 1, Part E from 4-amino-3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)benzonitrile dihydrochloride (0.135 g, 0.445 mmol) and benzo[b]thiophene-2-sulfonyl chloride (0.114 g, 0.49 mmol) in acetonitrile.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06034093uspto-grants-2000_03