Reaction #171998

Reaction equation

2-bromo-4-fluorobenzonitrile

D-phenylalanine amide

DIEA

→

(R)-2-(3-bromo-4-cyanophenylamino)-3-phenylpropanamide

Yield 23.3%

Solvents

DMSO

Conditions

Workup

1. 1
   OtherThe mixture was then purified by HPLC

Procedure

A solution of 2-bromo-4-fluorobenzonitrile (255 mg, 1.27 mmol), D-phenylalanine amide (220 mg, 1.34 mmol) and DIEA (0.466 mL, 2.68 mmol) in DMSO (3 mL) was stirred at 100 C for 18 h. The mixture was then purified by HPLC to give (R)-2-(3-bromo-4-cyanophenylamino)-3-phenylpropanamide (102 mg).

Source