Reaction #1715

Reaction equation

N-(1-butyl-4-piperidinyl)methylamine

5-Chloro-2-methylbenzoxazole-7-carboxylic acid

oxalyl chloride

→

title compound

N-[(1-Butyl-4-piperidinyl)methyl]5-chloro-2-methylbenzoxazole-7-carboxamide

Solvents

triethylamine

Conditions

Procedure

5-Chloro-2-methylbenzoxazole-7-carboxylic acid (Ger. Offen. 2,225,544) is converted to its acid chloride by treatment with oxalyl chloride. The acid chloride is treated with N-(1-butyl-4-piperidinyl)methylamine in the presence of triethylamine to afford the title compound.

Source