Reaction #170986

Reaction equation

6-(4-nitrophenoxy)-hexanoic acid methyl ester

6-(4-Nitrophenoxy)-hexanoic acid methyl ester

→

35

Yield 80.2%

6-(4-Nitrophenoxy)-hexanoic acid

Yield 80.2%

Solvents

HCl

Conditions

Workup

1. 1
   TemperatureThe reaction mixture was cooled to room temp.
2. 2
   Filtrationfiltered
3. 3
   Otherdried
4. 4
   Otherrecrystallised from a mixture of ethyl acetate:hexane (1:6)

Procedure

6-(4-nitrophenoxy)-hexanoic acid methyl ester 21 (125 g, 468.16 mmol) was refluxed in conc. HCl (1250 ml) for 16 hours. The reaction mixture was cooled to room temp., filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:6) to get pure 35 (95 g, 80.2%) as a white powder with an m.p. between 104-107° C.

Source