Reaction #1702060

Reaction equation

N-(3-amino-3-oxo-propyl)-4-[(1S)-3-oxocyclopentyl]benzamide

(1R)-1-(1,3-benzodioxol-4-yl)ethanamine hydrochloride

→

N-(3-amino-3-oxo-propyl)-4-[(1S,3R/S)-3-[[(1R)-1-(1,3-benzodioxol-4-yl)ethyl]amino]cyclopentyl]benzamide

Conditions

Procedure

General procedure B was followed using N-(3-amino-3-oxo-propyl)-4-[(1S)-3-oxocyclopentyl]benzamide as the ketone and (1R)-1-(1,3-benzodioxol-4-yl)ethanamine hydrochloride as the amine. 1H NMR (600 MHz, DMSO) δ 8.39 (t, 1H), 7.74 (d, J=8.2 Hz, 2H), 7.36-7.31 (m, 3H), 6.92 (d, J=7.8 Hz, 1H), 6.84-6.79 (m, 2H), 6.78-6.75 (m, 1H), 5.97 (s, 2H), 3.91 (q, J=6.7 Hz, 1H), 3.46-3.31 (m, 2H), 3.01-2.93 (m, 2H), 2.33 (t, 2H), 2.24-2.17 (m, 1H), 1.96-1.86 (m, 1H), 1.80-1.59 (m, 2H), 1.54-1.46 (m, 1H), 1.42-1.34 (m, 1H), 1.26 (d, J=6.7 Hz, 3H).

Source