Reaction #168904

ord-8b1771262c5e44ada19659657c7eb43e

Reaction equation

Nc1cccc(Sc2ccnc(Cl)n2)c1
3-(2-chloropyrimidin-4-ylthio)benzenamine
C=CC(=O)O
acrylic acid
→
C=CC(=O)Nc1cccc(Sc2ccnc(Cl)n2)c1
product
Yield 68.0%
C=CC(=O)Nc1cccc(Sc2ccnc(Cl)n2)c1
N-(3-(2-chloropyrimidin-4-ylthio)phenyl)acrylamide
Yield 68.0%

Reactants

Nc1cccc(Sc2ccnc(Cl)n2)c1
3-(2-chloropyrimidin-4-ylthio)benzenamine
C=CC(=O)O
acrylic acid

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

In a procedure analogous to Example 15, reaction of 3-(2-chloropyrimidin-4-ylthio)benzenamine (300 mg, 1.26 mmol) and acrylic acid (173 μL, 2.52 mmol) furnished the product (250 mg, 68%).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08846704B2uspto-grants-2014_09