Reaction #1687635

ord-1f3d63b3d76045508493ba53e1f22655

Reaction equation

O=C([O-])/C=C/C(=O)[O-]
fumarate
Cc1cnc(-c2cccnc2)s1
88
Cc1cnc(-c2cccnc2)s1
5-Methyl-2-(3-pyridyl)-thiazole
→
Cc1cnc(C2=CCCN(C)C2)s1
title compound
Cc1cnc(C2=CCCN(C)C2)s1
5-Methyl-2-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-thiazole

Reactants

O=C([O-])/C=C/C(=O)[O-]
fumarate
Cc1cnc(-c2cccnc2)s1
88
Cc1cnc(-c2cccnc2)s1
5-Methyl-2-(3-pyridyl)-thiazole
—
(C12H16N2O2S)C

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThe crude free base obtained

Procedure

The title compound was prepared from 88 (2.2 g, 0.013 mol) by the procedure described in Example 49. The crude free base obtained, 89, was converted to the title fumarate, 90. Yield: 0.8 g (0.0032 mol, 25%). M.P. 159°-160° C. Anal. (C12H16N2O2S)C, H, N.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: USRE036374uspto-grants-1999_11