Reaction #1677

Reaction equation

p-chlorobenzoic hydrazide

chloroacetyl chloride

→

N'-chloroacetyl-4-chlorobenzoic hydrazide

Solvents

dioxane

Conditions

Workup

1. 1
   TemperatureThe resulting mixture was refluxed for three hours
2. 2
   Filtrationfiltered
3. 3
   WashThe resulting solid was washed with ethyl ether
4. 4
   Otherdried

Procedure

To a solution of p-chlorobenzoic hydrazide (11.2 g) in dioxane (100 ml) was added chloroacetyl chloride (6 ml). The resulting mixture was refluxed for three hours, cooled to room temperature and filtered. The resulting solid was washed with ethyl ether and dried to yield N'-chloroacetyl-4-chlorobenzoic hydrazide as white solid.

Source