Reaction #167589

ord-91e166a743ba4135b34420db58a5da7d

Reaction equation

N#CCS(=O)(=O)Cc1ccc(C(F)(F)F)nc1
(6-trifluoromethyl-pyridin-3-ylmethanesulfonyl)-acetonitrile
O=S(=O)(OCCSC(F)(F)F)C(F)(F)F
trifluoro-methanesulfonic acid 2-trifluoromethylsulfanyl-ethyl ester
→
N#CC(CCSC(F)(F)F)S(=O)(=O)Cc1ccc(C(F)(F)F)nc1
2-(6-Trifluoromethyl-pyridin-3-ylmethanesulfonyl)-4-trifluoromethylsulfanyl-butyronitrile

Reactants

N#CCS(=O)(=O)Cc1ccc(C(F)(F)F)nc1
(6-trifluoromethyl-pyridin-3-ylmethanesulfonyl)-acetonitrile
O=S(=O)(OCCSC(F)(F)F)C(F)(F)F
trifluoro-methanesulfonic acid 2-trifluoromethylsulfanyl-ethyl ester

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Compound II-9 was prepared from (6-trifluoromethyl-pyridin-3-ylmethanesulfonyl)-acetonitrile and trifluoro-methanesulfonic acid 2-trifluoromethylsulfanyl-ethyl ester as described for compound II-1.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08846569B2uspto-grants-2014_09