Reaction #1672627

ord-4ee8761c431847b4bc4142ac07a1b402

Reaction equation

CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine HCl
N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O
glutathione
C[Si](C)(O[*:2])[*:1]
polydimethylsiloxane
→
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3
apomorphine

Reactants

CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine HCl
N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O
glutathione
C[Si](C)(O[*:2])[*:1]
polydimethylsiloxane
—
ethanolic solution

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    workup.ADDITIONmixing until the mixture

Procedure

An apomorphine transdermal patch formulation was prepared by adding 1 milliliter of a ethanolic solution of 20 mg/ml apomorphine HCl and 2.6 mg/ml glutathione to 2 g of polydimethylsiloxane 200 and mixing until the mixture congealed.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05939094uspto-grants-1999_08