Reaction #166464

Reaction equation

tert-butyl 2-(6-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)pyridin-2-yloxy)ethylcarbamate

hydrogen chloride

→

N-(1-((6-(2-aminoethoxy)pyridin-2-yl)methyl)-3-ethyl-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide dihydrochloride

Yield 69.0%

Solvents

ethyl acetate

Conditions

Workup

1. 1
   Otherthe solvent was removed under reduced pressure

Procedure

To a solution of tert-butyl 2-(6-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)pyridin-2-yloxy)ethylcarbamate (21.9 mg, 0.0394 mmol) in ethyl acetate was added hydrogen chloride (1 mL; 4M in dioxane). The mixture was stirred for 30 minutes and the solvent was removed under reduced pressure to give N-(1-((6-(2-aminoethoxy)pyridin-2-yl)methyl)-3-ethyl-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide dihydrochloride (14.3 mg; 69%). MS (APCI), positive scan, m/z=456.1 (M+H).

Source