Reaction #166271

ord-95e52d2662b04cc1b91e7386b25cb31e

Reaction equation

O=C(Nc1cccc(S(=O)(=O)NC2=NCCC2)c1)c1ccccc1Oc1ccccc1
N-[3-[[(3,4-dihydro-2H-pyrrol-5-yl)amino]sulfonyl]phenyl]-2-phenoxy-benzamide
O=C(Nc1cccc(S(=O)(=O)NC2CC2)c1)c1ccccc1Cc1ccccc1
N-[3-[(cyclopropylamino)sulfonyl]phenyl]-2-(phenylmethyl)-benzamide
COc1ccc(Oc2ccc([N+](=O)[O-])cc2C(=O)Nc2cccc(S(N)(=O)=O)c2)cc1
N-[3-(aminosulfonyl)phenyl]-2-(4-methoxyphenoxy)-5-nitro-benzamide
Cc1ccc(S(=O)(=O)N(C)C)cc1NC(=O)c1ccccc1Cc1ccccc1
N-[5-[(dimethylamino)sulfonyl]-2-methylphenyl]-2-(phenylmethyl)-benzamide
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccccc2Sc2ccccc2C#N)c1
2-[(2-cyanophenyl)thio]-N-[5-[(diethylamino)sulfonyl]-2-methylphenyl]-benzamide
CN(C)S(=O)(=O)c1cccc(NC(=O)c2ccccc2Oc2ccccc2)c1
N-[3-[(dimethylamino)sulfonyl]phenyl]-2-phenoxy-benzamide
CCNS(=O)(=O)c1ccc(OC)c(NC(=O)c2ccccc2C(=O)c2ccc(Cl)c([N+](=O)[O-])c2)c1
2-(4-chloro-3-nitrobenzoyl)-N-[5-[(ethylamino)sulfonyl]-2-methoxyphenyl]-benzamide
CCN(CC)S(=O)(=O)c1ccc(OC)c(NC(=O)c2ccccc2Sc2ccccc2C#N)c1
2-[(2-cyanophenyl)thio]-N-[5-[(diethylamino)sulfonyl]-2-methoxyphenyl]-benzamide
Cc1ccc(S(=O)(=O)N(C)C)cc1NC(=O)c1ccccc1Sc1ccc(C(F)(F)F)cc1[N+](=O)[O-]
N-[5-[(dimethylamino)sulfonyl]-2-methylphenyl]-2-[[2-nitro-4-(trifluoromethyl)phenyl]thio]-benzamide
COc1ccc(NC(=O)c2ccccc2C(=O)c2ccc(SC)c([N+](=O)[O-])c2)cc1S(N)(=O)=O
N-[3-(aminosulfonyl)-4-methoxyphenyl]-2-[4-(methylthio)-3-nitrobenzoyl]-benzamide
COc1ccc(S(=O)(=O)N(C)C)cc1NC(=O)c1ccccc1Oc1ccccc1
N-[5-[(dimethylamino)sulfonyl]-2-methoxyphenyl]-2-phenoxy-benzamide
O=C(Nc1cccc(S(=O)(=O)NCc2ccco2)c1)c1ccccc1Nc1ccc(SC(F)F)cc1
2-[[4-[(difluoromethyl)thio]phenyl]amino]-N-[3-[[(2-furanylmethyl)amino]sulfonyl]phenyl]-benzamide
Cc1cc(S(=O)(=O)N(C)C)cc(NC(=O)c2ccccc2Sc2ccccc2C#N)c1C
2-[(2-cyanophenyl)thio]-N-[5-[(dimethylamino)sulfonyl]-2,3-dimethylphenyl]-benzamide
CCN(CC)S(=O)(=O)c1cc(C)c(C)c(NC(=O)c2ccccc2Sc2ccccc2C#N)c1
2-[(2-cyanophenyl)thio]-N-[5-[(diethylamino)sulfonyl]-2,3-dimethylphenyl]-benzamide
→
O=C(Nc1cccc(S(=O)(=O)NC2CC2)c1)c1ccccc1Oc1ccccc1
N-[3-[(cyclopropylamino)sulfonyl]phenyl]-2-phenoxy-benzamide

Reactants

O=C(Nc1cccc(S(=O)(=O)NC2=NCCC2)c1)c1ccccc1Oc1ccccc1
N-[3-[[(3,4-dihydro-2H-pyrrol-5-yl)amino]sulfonyl]phenyl]-2-phenoxy-benzamide
O=C(Nc1cccc(S(=O)(=O)NC2CC2)c1)c1ccccc1Cc1ccccc1
N-[3-[(cyclopropylamino)sulfonyl]phenyl]-2-(phenylmethyl)-benzamide
COc1ccc(Oc2ccc([N+](=O)[O-])cc2C(=O)Nc2cccc(S(N)(=O)=O)c2)cc1
N-[3-(aminosulfonyl)phenyl]-2-(4-methoxyphenoxy)-5-nitro-benzamide
Cc1ccc(S(=O)(=O)N(C)C)cc1NC(=O)c1ccccc1Cc1ccccc1
N-[5-[(dimethylamino)sulfonyl]-2-methylphenyl]-2-(phenylmethyl)-benzamide
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccccc2Sc2ccccc2C#N)c1
2-[(2-cyanophenyl)thio]-N-[5-[(diethylamino)sulfonyl]-2-methylphenyl]-benzamide
CN(C)S(=O)(=O)c1cccc(NC(=O)c2ccccc2Oc2ccccc2)c1
N-[3-[(dimethylamino)sulfonyl]phenyl]-2-phenoxy-benzamide
CCNS(=O)(=O)c1ccc(OC)c(NC(=O)c2ccccc2C(=O)c2ccc(Cl)c([N+](=O)[O-])c2)c1
2-(4-chloro-3-nitrobenzoyl)-N-[5-[(ethylamino)sulfonyl]-2-methoxyphenyl]-benzamide
CCN(CC)S(=O)(=O)c1ccc(OC)c(NC(=O)c2ccccc2Sc2ccccc2C#N)c1
2-[(2-cyanophenyl)thio]-N-[5-[(diethylamino)sulfonyl]-2-methoxyphenyl]-benzamide
Cc1ccc(S(=O)(=O)N(C)C)cc1NC(=O)c1ccccc1Sc1ccc(C(F)(F)F)cc1[N+](=O)[O-]
N-[5-[(dimethylamino)sulfonyl]-2-methylphenyl]-2-[[2-nitro-4-(trifluoromethyl)phenyl]thio]-benzamide
COc1ccc(NC(=O)c2ccccc2C(=O)c2ccc(SC)c([N+](=O)[O-])c2)cc1S(N)(=O)=O
N-[3-(aminosulfonyl)-4-methoxyphenyl]-2-[4-(methylthio)-3-nitrobenzoyl]-benzamide
COc1ccc(S(=O)(=O)N(C)C)cc1NC(=O)c1ccccc1Oc1ccccc1
N-[5-[(dimethylamino)sulfonyl]-2-methoxyphenyl]-2-phenoxy-benzamide
O=C(Nc1cccc(S(=O)(=O)NCc2ccco2)c1)c1ccccc1Nc1ccc(SC(F)F)cc1
2-[[4-[(difluoromethyl)thio]phenyl]amino]-N-[3-[[(2-furanylmethyl)amino]sulfonyl]phenyl]-benzamide
Cc1cc(S(=O)(=O)N(C)C)cc(NC(=O)c2ccccc2Sc2ccccc2C#N)c1C
2-[(2-cyanophenyl)thio]-N-[5-[(dimethylamino)sulfonyl]-2,3-dimethylphenyl]-benzamide
CCN(CC)S(=O)(=O)c1cc(C)c(C)c(NC(=O)c2ccccc2Sc2ccccc2C#N)c1
2-[(2-cyanophenyl)thio]-N-[5-[(diethylamino)sulfonyl]-2,3-dimethylphenyl]-benzamide

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

N-[3-[[(3,4-dihydro-2H-pyrrol-5-yl)amino]sulfonyl]phenyl]-2-phenoxy-benzamide; N-[3-[(dimethylamino)sulfonyl]phenyl]-2-phenoxy-benzamide; N-[5-[(dimethylamino)sulfonyl]-2-methoxyphenyl]-2-phenoxy-benzamide; N-[3-(aminosulfonyl)phenyl]-2-(4-methoxyphenoxy)-5-nitro-benzamide; N-[3-[(cyclopropylamino)sulfonyl]phenyl]-2-(phenylmethyl)-benzamide; 2-[(2-cyanophenyl)thio]-N-[5-[(dimethylamino)sulfonyl]-2,3-dimethylphenyl]-benzamide; 2-[(2-cyanophenyl)thio]-N-[5-[(diethylamino)sulfonyl]-2,3-dimethylphenyl]-benzamide; N-[5-[(dimethylamino)sulfonyl]-2-methylphenyl]-2-(phenylmethyl)-benzamide; 2-[(2-cyanophenyl)thio]-N-[5-[(diethylamino)sulfonyl]-2-methylphenyl]-benzamide; N-[5-[(dimethylamino)sulfonyl]-2-methylphenyl]-2-[[2-nitro-4-(trifluoromethyl)phenyl]thio]-benzamide; 2-[(2-cyanophenyl)thio]-N-[5-[(diethylamino)sulfonyl]-2-methoxyphenyl]-benzamide; N-[3-(aminosulfonyl)-4-methoxyphenyl]-2-[4-(methylthio)-3-nitrobenzoyl]-benzamide; 2-(4-chloro-3-nitrobenzoyl)-N-[5-[(ethylamino)sulfonyl]-2-methoxyphenyl]-benzamide; and 2-[[4-[(difluoromethyl)thio]phenyl]amino]-N-[3-[[(2-furanylmethyl)amino]sulfonyl]phenyl]-benzamide.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08841483B2uspto-grants-2014_09