Reaction #165751

Reaction equation

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide

triethylamine

benzoyl chloride

→

product

Yield 70.0%

3-amino-N′-(benzoyloxy)-6-bromopyrazine-2-carboximidamide

Yield 70.0%

Solvents

DCM

Conditions

Workup

1. 1
   workup.ADDITIONwere added
2. 2
   Otherthe solvent was removed in vacuo
3. 3
   Otherthe residue triturated with MeOH
4. 4
   FiltrationThe resultant filtrate was filtered off

Procedure

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide (770 mg, 3.318 mmol) was suspended in DCM (10 mL) and triethylamine (369.3 mg, 508.7 μL, 3.650 mmol) followed by benzoyl chloride (513.1 mg, 423.7 μL, 3.650 mmol) were added. After 1 hour, the solvent was removed in vacuo and the residue triturated with MeOH. The resultant filtrate was filtered off to furnish the product as an off-white solid (779 mg, 70% Yield).

Source