Reaction #164813

Reaction equation

4-chlorobenzyl piperazine-1-carboxylate hydrochloride

1-hydroxybenzotriazole

N-methylmorpholine

3-dimethylaminopropylcarbodiimide hydrochloride

→

4-chlorobenzyl 4-(2-1H-benzotriazol-5-ylacetyl)piperazine-1-carboxylate

Solvents

DMF

Conditions

Procedure

7.3 220 mg (1.24 mmol) of 23, 362 mg (1.24 mmol) of 4-chlorobenzyl piperazine-1-carboxylate hydrochloride, 168 mg (1.24 mmol) of 1-hydroxybenzotriazole (HOBt), 143 mg (1.24 mmol) of N-methylmorpholine and 238 mg (1.24 mmol) of 3-dimethylaminopropylcarbodiimide hydrochloride (DAPECI) are stirred at RT for 48 h in 10 ml of DMF.

Source