Reaction #163523

Reaction equation

2-bromo-6-aminophenol

1.8-diazabicyclo[5.4.0]undec-7-ene

DL-Ethyl 2-bromobutyrate

→

8-bromo-2-ethyl-2H-benzo[b][1,4]oxazin-3(4H)-one

Yield 71.0%

Solvents

1-Methyl-2-pyrrolidinone

Conditions

Workup

1. 1
   Other1.447 g of P1 were obtained

Procedure

Procedure & NMR Data: 1.5 g (7.9 mmol) of 2-bromo-6-aminophenol, 1.08 ml (0.9 eq, 7.11 mmol) of 1.8-diazabicyclo[5.4.0]undec-7-ene and 3.5 mL of DL-Ethyl 2-bromobutyrate (3 eq, 23.7 mmol)) in 30 mL of 1-Methyl-2-pyrrolidinone were mixed. 1.447 g of P1 were obtained, yield 71%.

Source