Reaction #1632

ord-d63aff1397e8480b8c2a33699be1bede

Reaction equation

CCCCOP(=O)(COc1ccccc1)C1CCC(CCN)CC1
4-(2-aminoethyl)phenoxy methylcyclohexylphosphinic acid, n-butyl ester
c1ccc(COc2ccc(OC[C@@H]3CO3)cc2)cc1
(S)-2-(4-benzyloxyphenoxymethyl)oxirane
→
CCCCO[P@](=O)(COc1ccccc1)C1CCC(CCNCC(O)COc2ccc(OCc3ccccc3)cc2)CC1
title compound
CCCCO[P@](=O)(COc1ccccc1)C1CCC(CCNCC(O)COc2ccc(OCc3ccccc3)cc2)CC1
(S)-4-{2-[3-(4-Benzyloxyphenoxy)-2-hydroxypropylamino]ethyl}phenoxymethylcyclohexylphosphinic acid, n-butyl ester

Reactants

CCCCOP(=O)(COc1ccccc1)C1CCC(CCN)CC1
4-(2-aminoethyl)phenoxy methylcyclohexylphosphinic acid, n-butyl ester
c1ccc(COc2ccc(OC[C@@H]3CO3)cc2)cc1
(S)-2-(4-benzyloxyphenoxymethyl)oxirane

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound was prepared from 4-(2-aminoethyl)phenoxy methylcyclohexylphosphinic acid, n-butyl ester and (S)-2-(4-benzyloxyphenoxymethyl)oxirane according to the method described in Procedure 13.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05726165uspto-grants-1998_03