Reaction #1622

Reaction equation

(R)-5-(2-aminopropyl)-1,3-benzodioxole-2,2-dicarboxylic acid diethyl ester hydrochloride

sodium hydrogen carbonate

→

title compound

(R)-5-(2-Aminopropyl)-1,3-benzodioxole-2,2-dicarboxylic acid, diethyl ester

Solvents

dichloromethane

Conditions

Workup

1. 1
   OtherThe organic layer was separated
2. 2
   Extractionthe aqueous layer was extracted with dichloromethane (2×50 ml)
3. 3
   WashThe combined organic extracts were washed with water (50 ml) and brine (50 ml)
4. 4
   Dryingdried (MgSO4)
5. 5
   OtherThe solvent was evaporated

Procedure

A solution of (R)-5-(2-aminopropyl)-1,3-benzodioxole-2,2-dicarboxylic acid diethyl ester hydrochloride (646 mg, 2 mMol) in dichloromethane (80 ml) was shaken with a saturated solution of sodium hydrogen carbonate (20 ml) for 30 seconds. The organic layer was separated and the aqueous layer was extracted with dichloromethane (2×50 ml). The combined organic extracts were washed with water (50 ml) and brine (50 ml), dried (MgSO4). The solvent was evaporated giving the title compound which was used immediately.

Source