Reaction #1621907

Reaction equation

ethyl 4[[1-[(2-pyridinyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate

hydrobromic acid

→

N-(4-piperidinyl)-1-[(2-pyridinyl)methyl]-1H-benzimidazol-2-amine trihydrobromide

Yield 93.2%

Solvents

water

Conditions

Workup

1. 1
   OtherThe reaction mixture was evaporated
2. 2
   Otherthe residue was crystallized from methanol

Procedure

A mixture of 30 parts of ethyl 4[[1-[(2-pyridinyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate and 300 parts of a hydrobromic acid solution 48% in water was stirred and heated for 3 hours at 80° C. The reaction mixture was evaporated and the residue was crystallized from methanol, yielding 41 parts (93.2%) of N-(4-piperidinyl)-1-[(2-pyridinyl)methyl]-1H-benzimidazol-2-amine trihydrobromide; mp. 295.9° C. (intermediate 60).

Source