Reaction #1608

Reaction equation

6-(4-chlorophenyl)-pyridazinone

phosphorus pentasulfide

→

6-(4-chlorophenyl)-pyridazinthione

Yield 187.1%

Solvents

pyridine

Conditions

Workup

1. 1
   Temperaturewas refluxed for 1 hour
2. 2
   Otherevaporated to dryness
3. 3
   Extractionextracted with 200 ml of ether
4. 4
   ExtractionThe ether extract
5. 5
   Washwas washed with water (3×100 ml), brine (100 ml)
6. 6
   Dryingdried over magnesium sulfate
7. 7
   Otherevaporated

Procedure

A mixture of 3.0 g of 6-(4-chlorophenyl)-pyridazinone, 50 ml of dry pyridine and 3.2 g of phosphorus pentasulfide was refluxed for 1 hour, evaporated to dryness and extracted with 200 ml of ether. The ether extract was washed with water (3×100 ml), brine (100 ml), dried over magnesium sulfate and evaporated to yield 3.0 g of 6-(4-chlorophenyl)-pyridazinthione as a yellow solid.

Source