Reaction #160676

Reaction equation

phosphate

(3RS,4SR)-3-(3,4-dimethoxyphenyl)-4-nitrocyclohexanone

compound F2

(3RS,4SR)-3-(3,4-dimethoxyphenyl)-4-nitrocyclohexanone

potassium tri-sec-butylborohydride

→

title compound

(1 RS,3RS,4SR)-3-(3,4-Dimethoxyphenyl)-4-n itrocyclohexanol

Solvents

tetrahydrofurane

tetrahydrofurane

ethyl acetate

Conditions

Workup

1. 1
   workup.ADDITIONis added
2. 2
   workup.STIRRINGStirring
3. 3
   workup.WAITis continued for further 10 min
4. 4
   Extractionthe aqueous layer is extracted with ethyl acetate
5. 5
   Concentrationthe combined organic phases are concentrated
6. 6
   Otherto give a foam, which
7. 7
   Otheris purified by chromatography on silica gel using
8. 8
   workup.ADDITIONa mixture of petroleum ether/ethyl acetate in the ratio 1/1

Procedure

Under nitrogen atmosphere 16.76 g of (3RS,4SR)-3-(3,4-dimethoxyphenyl)-4-nitrocyclohexanone (compound F2) are dissolved in 300 ml of tetrahydrofurane, the solution is cooled to −78° C., and 75 ml of 1 M solution of potassium tri-sec-butylborohydride in tetrahydrofurane is added dropwise. After stirring for further 1 h, a mixture consisting of 30% hydrogeneperoxide solution and phosphate buffer solution is added. Stirring is continued for further 10 min, the reaction mixture is diluted with 400 ml of ethyl acetate and the aqueous layer is extracted with ethyl acetate, the combined organic phases are concentrated to give a foam, which is purified by chromatography on silica gel using a mixture of petroleum ether/ethyl acetate in the ratio 1/1 to furnish 10.18 g (60% of theory) of the title compound.

Source