Reaction #1605767

Reaction equation

sodium acetate

5-Methoxy-2,3-dihydromden-1-one

hydroxylamine HCl

→

5-methoxy-2,3-dihydroinden-1-one oxime

Solvents

H2O

MeOH

THF

H2O

water

Conditions

Workup

1. 1
   Otherwas brought up to 70° C.
2. 2
   Otherto produce a precipitate
3. 3
   workup.STIRRINGto stir for 2 h
4. 4
   FiltrationThe precipitate was collected by filtration

Procedure

5-Methoxy-2,3-dihydromden-1-one (Ig, 6.17 mmol) was added to a solution of hydroxylamine HCl (730 mg, 10.5 mmol) in 10 ml of water. The mixture was brought up to 70° C. and a solution of sodium acetate (1.4 g, 16.7 mmol) in 7 mL of H2O, 14 ml of MeOH, 3 ml of THF was added. After stirring for 1.5 h at 70° C., 10 ml of H2O was added to produce a precipitate and the suspension was allowed to stir for 2 h. The precipitate was collected by filtration to give 5-methoxy-2,3-dihydroinden-1-one oxime almost quantitatively and was used in the next step without further purification. The oxime (0.5 g, 2.82 mmol) was dissolved in MeOH and a catalytic amount of Raney nickel and 25 mL of ammonia solution in MeOH (7N) was added. The reaction was stirred at r.t. overnight under H2. The slurry was filtered over celite and concentrated in vacuo, diluted with EtOAc, washed with water and brine, dried over MgSO4, filtered, and concentrated in vacuo to give the crude title amine (yield, 45%). The crude amine was used without further purification.

Source