Reaction #160040

ord-9c0abc16bb574c42ba9e4d3b1cac9333

Reaction equation

[Br-].[CH3][Mg+]
MeMgBr
O=C(O)CC1CCC(=O)CC1
(4-Oxo-cyclohexyl)-acetic acid
→
CC1(O)CCC(CC(=O)O)CC1
(4-Hydroxy-4-methyl-cyclohexyl)-acetic acid

Reactants

[Br-].[CH3][Mg+]
MeMgBr
O=C(O)CC1CCC(=O)CC1
(4-Oxo-cyclohexyl)-acetic acid
—
( 1 )

Reagents

None

Solvents

C1CCOC1
THF

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherPrepared

Procedure

Prepared using an excess of MeMgBr (26 mmol) in THF (20 ml) with (4-Oxo-cyclohexyl)-acetic acid (13 mmol) as described on Journal of American Society 93 (1), 1971, 121-129.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08829029B2uspto-grants-2014_09