Reaction #1596999

Reaction equation

5-aminosalicylic acid

4-methoxybenzyl chloride

→

5-(4-methoxybenzyl)aminosalicylic acid

Yield 50.0%

Conditions

Workup

1. 1
   Otherin Synthesis Example 1

Procedure

By following the similar procedure in Synthesis Example 1 by using 5-aminosalicylic acid (1.00 g, 6.53 mmole) and 4-methoxybenzyl chloride (1.23 g, 7.84 mmole), 890 mg (50% yield) of 5-(4-methoxybenzyl)aminosalicylic acid was obtained as a white solid.:mp 205-206° C.

Source