Reaction #1596973

Reaction equation

p-hydroxybenzoic acid

8-bromo-1-octene

potassium carbonate

N,N-dimethylacetamide

→

4-(7-octenyloxy)-benzoic acid

Solvents

water

Conditions

Workup

1. 1
   TemperatureAfter cooled
2. 2
   Extractionextracted with ethyl acetate (500 mL)
3. 3
   Washwashed two times with water (100 mL)
4. 4
   DryingThis was dried with anhydrous magnesium sulfate
5. 5
   Filtrationfiltered
6. 6
   OtherThe solvent was removed through concentration under reduced pressure
7. 7
   workup.DISSOLUTIONthe residue was dissolved in methanol (100 mL)
8. 8
   workup.ADDITIONgradually added
9. 9
   Temperatureheated
10. 10
    Temperatureunder reflux for 2 hours
11. 11
    TemperatureAfter cooled
12. 12
    Filtrationthe formed crystal was collected through filtration
13. 13
    Washwashed with water
14. 14
    OtherThis was dried
15. 15
    Otherto give TP-5C (63.3 g, 85%)

Procedure

p-hydroxybenzoic acid (33.2 g), 8-bromo-1-octene (57.3 g), potassium carbonate (41.5 g) and N,N-dimethylacetamide (200 mL) were put into a 500-mL three-neck flask, and stirred at 120° C. for 5 hours. After cooled, the reaction mixture was poured into water (200 mL), extracted with ethyl acetate (500 mL), and washed two times with water (100 mL). This was dried with anhydrous magnesium sulfate and then filtered. The solvent was removed through concentration under reduced pressure, the residue was dissolved in methanol (100 mL), and a methanol solution (20 mL) of potassium hydroxide (16.8 g) was dropwise and gradually added thereto, and heated under reflux for 2 hours. After cooled, the formed crystal was collected through filtration and washed with water. This was dried to give TP-5C (63.3 g, 85%).

Source