Reaction #1583893

Reaction equation

2-Fluoro-4-methylbenzoic acid

MeOH

HCl

→

Intermediate ( 6a )

2-Fluoro-4-methylbenzoic acid methyl ester

Conditions

Workup

1. 1
   TemperatureThe mixture was heated
2. 2
   Temperatureto reflux
3. 3
   Temperaturecooled
4. 4
   Concentrationconcentrated
5. 5
   OtherThe recovered material was dried in vacuo for 24 hours

Procedure

2-Fluoro-4-methylbenzoic acid (30.0 g, 195 mmol) was dissolved in MeOH (600 mL, 10 mol), and 12 M HCl (3.2 mL, 39 mmol) was added. The mixture was heated to reflux and stirred for 48 hours, then cooled and concentrated. The recovered material was dried in vacuo for 24 hours to obtain Intermediate (6a) as a white solid that was used without further purification.

Source