Reaction #1583808

Reaction equation

bromine

1-(5-chloro-2-thienyl)-2-(pyridin-4-yl)ethanone

→

2-Bromo-1-(5-chloro-2-thienyl)-2-(pyridin-4-yl)ethanone

Solvents

acetic acid

Conditions

Workup

1. 1
   FiltrationThe resulting precipitate is filtered off
2. 2
   Washwashed with MTBE
3. 3
   Otherdried

Procedure

At room temperature, 26.9 g (167 mmol) of bromine are added dropwise to a solution of 40.0 g (167 mmol) of 1-(5-chloro-2-thienyl)-2-(pyridin-4-yl)ethanone in 200 ml of acetic acid, and the mixture is stirred for 90 min. The resulting precipitate is filtered off, washed with MTBE and dried. This gives 64.5 g (96%) of the desired product; log P (pH2.7): 2.18 with MS (ESI): 315.9 ([M+H]+).

Source