Reaction #157548

Reaction equation

tert-butyl (5-(hydroxymethyl)-4H-1,2,4-triazol-3-yl)carbamate

2-amino-4-chlorobenzenethiol

PPh3

di-tert-butylazodicarboxylate

→

title compound

tert-butyl (5-(((2-amino-4-chlorophenyl)thio)methyl)-4H-1,2,4-triazol-3-yl)carbamate

Solvents

CH2Cl2

Conditions

Workup

1. 1
   OtherThe solvent was then removed

Procedure

A solution of tert-butyl (5-(hydroxymethyl)-4H-1,2,4-triazol-3-yl)carbamate (190 mg, 0.888 mmol), 2-amino-4-chlorobenzenethiol (213 mg, 1.332 mmol), PPh3 (466 mg, 1.776 mmol) and di-tert-butylazodicarboxylate (409 mg, 1.776 mmol) in CH2Cl2 (10 ml) was stirred at room temperature for 2 days. The solvent was then removed and the crude residues was loaded on silica gel column to get the title compound.

Source