Reaction #1568370

Reaction equation

1-cyano-4-hydroxy-7-phenylsulfanyl-isoquinoline-3-carboxylic acid methyl ester

1-aminomethyl-cyclobutanecarboxylic acid tert-butyl ester

→

desired product

Yield 92.7%

1-{[(1-Cyano-4-hydroxy-7-phenylsulfanyl-isoquinoline-3-carbonyl)-amino]-methyl}-cyclobutanecarboxylic acid tert-butyl ester

Yield 92.7%

Solvents

EtOH

Conditions

Workup

1. 1
   Otherwas microwaved at 140° C. for 1 h
2. 2
   TemperatureThe mixture was cooled
3. 3
   Concentrationconcentrated
4. 4
   Otherpurified

Procedure

A mixture of 1-cyano-4-hydroxy-7-phenylsulfanyl-isoquinoline-3-carboxylic acid methyl ester (43 mg) and 1-aminomethyl-cyclobutanecarboxylic acid tert-butyl ester (48 mg) in EtOH (0.5 mL) was microwaved at 140° C. for 1 h. The mixture was cooled, concentrated and the residue was column purified to give the desired product (58 mg). LC MS ESI+: 490 (M+1)+.

Source