Reaction #156693

ord-5f86081235cc4d8ba012c513812c2ded

Reaction equation

CC1(O)CCN([C@@H]2CCN(c3ccc(N)cc3F)C2)CC1
1-[(R)-1-(4-Amino-2-fluoro-phenyl)-pyrrolidin-3-yl]-4-methyl-piperidin-4-ol
O=C1OCCc2cc(OC[C@@H]3CCCO3)ccc21
6-[(S)-1-(Tetrahydro-furan-2-yl)methoxy]-isochroman-1-one
→
CC1(O)CCN([C@@H]2CCN(c3ccc(N4CCc5cc(OC[C@@H]6CCCO6)ccc5C4=O)cc3F)C2)CC1
2-{3-Fluoro-4-[(R)-3-(4-hydroxy-4-methyl-piperidin-1-yl)-pyrrolidin-1-yl]-phenyl}-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one

Reactants

CC1(O)CCN([C@@H]2CCN(c3ccc(N)cc3F)C2)CC1
1-[(R)-1-(4-Amino-2-fluoro-phenyl)-pyrrolidin-3-yl]-4-methyl-piperidin-4-ol
O=C1OCCc2cc(OC[C@@H]3CCCO3)ccc21
6-[(S)-1-(Tetrahydro-furan-2-yl)methoxy]-isochroman-1-one

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThe product with the molecular weight of 523.65 (C30H38FN3O4) was obtained in this way

Procedure

1-[(R)-1-(4-Amino-2-fluoro-phenyl)-pyrrolidin-3-yl]-4-methyl-piperidin-4-ol was reacted with 6-[(S)-1-(Tetrahydro-furan-2-yl)methoxy]-isochroman-1-one by method AC. The product with the molecular weight of 523.65 (C30H38FN3O4) was obtained in this way; MS (ESI): 524 (M+H+).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822495B2uspto-grants-2014_09